Quest for Genes Regulating Plasma Fibrinogen Concentration

Quest for genes regulating plasma fibrinogen concentration: still a long way to go.

Identification of the genes and genetic variants that confer proneness to coronary heart disease (CHD) remains an outstanding challenge to the biomedical research community. A host of genes are likely to contribute, yet only a small fraction have so far been unequivocally identified. This is not least because of the limited increase in risk contributed by each susceptibility gene. Thus, in most...

Common structural genes for platelet and plasma fibrinogen.

Fibrinogen from plasma was compared with fibrinogen from platelets using two-dimensional electrophoresis. The source of platelet fibrinogen was isolated alpha-granules, thrombin- and collagen-released platelet material. The B beta- and gamma-chains from the different sources showed similar two-dimensional patterns, while gamma'-chains were not observed in platelet fibrinogen preparations. Furth...

Influence of fibrinogen concentration upon plasma prothrombin time.

A rapid "side-room" method for the determination of plasma fibrinogen concentration as fibrin.

A method is proposed for the rapid estimation of plasma fibrinogen concentration. The technique depends on the increase of optical density occurring when plasma clots. A kit is described which obviates the use of laboratory apparatus, so that the test may be performed in the ward side-room if a small centrifuge can be provided.A calibration curve has been prepared for use with commercial opacit...

Routine measurement of fibrinogen concentration

people with diabetes are more concerned about losing their driving licences (as a result of severe hypoglycaemia) than the risk of renal failure later. We may therefore be overestimating the impact of the diabetes control and complications trial on our patients' acceptance of stricter control. Certainly we need to pursue better methods of applying good glycaemic control in our diabetic patients...